Scientific working groups  Bioinformatics

Computational stem cell biology

Initiators: Ingo Roeder (Dresden) and Georg Fuellen (Rostock)

The computational or systems biological analysis of experimental data has become an indispensable part of modern biology in general and of stem cell biology in particular.  This is immediately visible in the area of the statistical/bioinformatical analysis of molecular high-throughput data: The complexity and the huge amount of data is simply not manageable without computational methods. But also in other areas of stem cell biology it is becoming more and more evident that theoretical approaches, such as mathematical modeling and computer simulation are able to contribute essentially to the generation of new insights.  

A selection of important questions that can be addressed with mathematical and/or bioinformatical methods is listed below:

  • How can the vast amount of different experimental data (e.g. measurements of the transcriptom, proteome, metabolom, but also image data) be analyzed in a structured way and how can the extracted information be integrated and correctly interpreted?
  • How are different regulatory components (e.g. transcription factors, signaling molecules, cell-cell interactions) linked to each other and which causal relations exist between them?
  • To what extent is it possible to explain phenomena on the cellular and tissue levels (e.g. the repopulation of the differentiation potential of stem cells) on the basis of intra-cellular and molecular mechanisms. 
  • Can one (prospectively) classify and predict functional properties of stem cells using molecular or phenomenological characteristics?
  • Are existing hypotheses/concepts/theories regarding various properties of stem cell systems quantitatively consistent with experimental findings?

To efficiently identify and address these or similar questions in close collaboration between experimentalists and theoreticians, we established the working group on “Computational stem cell biology”.  This working group has the aim to bundle and to intensify the application of theoretical approaches within the GSCN and to make these approaches more visible within but also outside the GSCN. It will provide a platform, which on the one hand fosters methodological discussion within fields of mathematical modelling, bioinformatics, and biometry applied to stem cell related topics, but which on the other hand also enforces the communication and the exchange of ideas with experimentally working scientists.

Past events:

GSCN workshop on computational biology

The working group "Computational stem cell biology"  organized a workshop on Computational Biology in Dresden on December 1st and 2nd, 2014. Please find further details on the website of the  TU Dresden.

6th Bioinformatics and Stem Cells Satellite Workshop

The GSCN is the main sponsor of the 6th Bioinformatics and Stem Cells Satellite Workshop which will be held after the 8th International Meeting of the Stem Cell Network NRW from 22 – 23 April 2015 in Bonn.

Further information can be found  here and  here (external website).


 StemCellMathLab 2016: 8th International Workshop on Models and Concepts of Stem Cell Organization

Systems medicine for leukemia treatment

16 - 18 June, 2016 - Hamburg, Germany

Organizer: Ingo Roeder / Ingmar Glauche (scientific organization)
Institute for Medical Informatics and Biometry (IMB)
Dresden University of Technology
Blasewitzer Strasse 86 (Office), 01307 Dresden, Germany

phone: +49 (0) 351 458 6060

Further information:

 Research on computational stem cell biology in Germany (GSCN Annual Magazine 2013/14)

 Bioinformatics analysis (GSCN Annual Magazine 2014/15)

Max Delbrueck Center for Molecular Medicine Berlin Stem Cell Network North Rhine Westphalia Partner Organizations Federal Ministry of Education and Research VDI Technologiezentrum