IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf
Team leader: Andrea Rossi
The Genome Engineering and Model Development (GEMD) lab uses induced pluripotent stem cells (iPSCs), iPSC- derived organoids, sequencing and genome engineering to model human diseases and investigate the molecular mechanism underlying genetic compensation.
The lab offers several services, including (but not limited to):
- Generation of genome engineering cells and animal models
- Generation of iPSC from somatic cells and iPSC-derived brain, lung and skin organoids
- DNA, RNA and scRNA sequencing using short and long reads.
The lab research focus is centered in the understanding of genetic compensation and its potential relationship with the environment. For this purpose, different models are being used, including iPSC and iPSC-brain organoids. The lab is also focused in developing new tools that facilitate scientific pipelines and or the analysis of data such as MAGECS, Duesselpore, CRISPRnano and Mitopore.
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